Tumor Markers in Prognosis of Gastric Cancer in the Kathmandu Valley

Gastric cancer was the fourth frequent cancer worldwide, and it was the subsequent most widespread basis of fatality from cancer. Gastric cancer is a multifactorial neoplastic pathology numbering among its causes both and genetic predisposing factors (Dikshit et al., 2011). Quite a lot of environmental factors are supposed to play a part in the development of gastric cancer such as diet rich in salted, smoked food exogenous chemicals and poor in fresh fruit and vegetables (Zagari et al., 2004). Highest morbidity percentages of gastric cancer are in South America and South-East Asia and it is comparatively barely diffused in Western countries and North America (Bertuccio et al., 2009). Serum tumor markers including alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen CA 19-9, and CA-50, have found to be raised in clinical or pathological stages of gastric cancer (Ishigami et al., 2001). CEA is a multifarious glycoprotein produced